Substituted benzimidazoles: A novel class of anti-tubercular agents

Novel class of semi synthetic natural products derived from lupeol as anti tubercular agents

Synthesis and SAR Study of Novel Amidino 2-substituted Benzimidazoles as Potential Antibacterial Agents

A series of novel 2-substituted benzimidazole derivatives were synthesized and their antibacterial activity was assessed against selected Gram-positive and Gram-negative bacteria. The specific moiety at the 2-position of the benzimidazole was extensively modified with several fused heterocyclic functional groups containing nitrogen and sulfur heteroatoms. In addition, the influence of different...

Alkaloids as potential anti-tubercular agents.

An increasing incidence of deaths due to tuberculosis and the known drawbacks of the current existing drugs including the emergence of multi drug-resistant strains have led to a renewed interest in the discovery of new anti-tubercular agents with novel modes of actions. The recent researches focused on natural products have shown a useful way to obtain a potentially rich source of drug candidat...

Spirooxindoles, a potential novel class of anti-inflammatory agents

In a previous study, we described a class of spirooxindole-pyranopyrimidine compounds that had a wide range of anti-cancer activity. In a most recent study, we found that one such compound, JP-8g, were also found to exhibit potent in vivo anti-inflammatory activity. In vitro and in vivo experiments suggested that JP-8g exerts this activity through nitric oxide (NO) signaling pathway. Herein, we...

The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents

We identified a di-substituted triazolopyrimidine with anti-tubercular activity against Mycobacterium tuberculosis. Three segments of the scaffold were examined rationally to establish a structure-activity relationship with the goal of improving potency and maintaining good physicochemical properties. A number of compounds displayed sub-micromolar activity against Mycobacterium tuberculosis wit...